Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.
Identifieur interne : 001316 ( Main/Exploration ); précédent : 001315; suivant : 001317Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.
Auteurs : Albrecht Von Brunn [Allemagne] ; Sandra Ciesek [Allemagne] ; Brigitte Von Brunn [Allemagne] ; Javier Carbajo-Lozoya [Allemagne]Source :
- Current opinion in virology [ 1879-6265 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- déficit : Cyclophiline A.
- génétique : Cyclophiline A.
- métabolisme : Cyclophiline A.
- physiologie : Coronavirus humain 229E.
- Humains, Interactions hôte-pathogène, Polymorphisme de nucléotide simple, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , deficiency : Cyclophilin A.
- chemical , genetics : Cyclophilin A.
- chemical , metabolism : Cyclophilin A.
- physiology : Coronavirus 229E, Human.
- Host-Pathogen Interactions, Humans, Polymorphism, Single Nucleotide, Virus Replication.
Abstract
Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of several viruses. Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication. We present data on the effect of cyclophilin A single nucleotide polymorphism mutants on the replication of human CoV-229E demonstrating the requirement of proper cyclophilin A function for virus propagation. Results define cellular cyclophilin A as a host target for inhibition of coronaviruses ranging from relatively mild common cold to highly pathogenic SARS-CoV and MERS-CoV viruses with the perspective of disclosing non-immunosuppressive cyclosporin A analogs to broadly inactivate the coronavirus family.
DOI: 10.1016/j.coviro.2015.08.004
PubMed: 26318518
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000D75
- to stream PubMed, to step Curation: 000D75
- to stream PubMed, to step Checkpoint: 000E18
- to stream Ncbi, to step Merge: 002B20
- to stream Ncbi, to step Curation: 002B20
- to stream Ncbi, to step Checkpoint: 002B20
- to stream Main, to step Merge: 001318
- to stream Main, to step Curation: 001316
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.</title><author><name sortKey="Von Brunn, Albrecht" sort="Von Brunn, Albrecht" uniqKey="Von Brunn A" first="Albrecht" last="Von Brunn">Albrecht Von Brunn</name><affiliation wicri:level="1"><nlm:affiliation>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF), Germany. Electronic address: vonbrunn@mvp.uni-muenchen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF)</wicri:regionArea><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion></affiliation></author><author><name sortKey="Ciesek, Sandra" sort="Ciesek, Sandra" uniqKey="Ciesek S" first="Sandra" last="Ciesek">Sandra Ciesek</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research (DZIF), Germany; Department of Gastroenterology, Hepatology und Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Germany; Department of Gastroenterology, Hepatology und Endocrinology, Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Von Brunn, Brigitte" sort="Von Brunn, Brigitte" uniqKey="Von Brunn B" first="Brigitte" last="Von Brunn">Brigitte Von Brunn</name><affiliation wicri:level="1"><nlm:affiliation>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF)</wicri:regionArea><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion></affiliation></author><author><name sortKey="Carbajo Lozoya, Javier" sort="Carbajo Lozoya, Javier" uniqKey="Carbajo Lozoya J" first="Javier" last="Carbajo-Lozoya">Javier Carbajo-Lozoya</name><affiliation wicri:level="1"><nlm:affiliation>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF)</wicri:regionArea><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26318518</idno><idno type="pmid">26318518</idno><idno type="doi">10.1016/j.coviro.2015.08.004</idno><idno type="wicri:Area/PubMed/Corpus">000D75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D75</idno><idno type="wicri:Area/PubMed/Curation">000D75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D75</idno><idno type="wicri:Area/PubMed/Checkpoint">000E18</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E18</idno><idno type="wicri:Area/Ncbi/Merge">002B20</idno><idno type="wicri:Area/Ncbi/Curation">002B20</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B20</idno><idno type="wicri:Area/Main/Merge">001318</idno><idno type="wicri:Area/Main/Curation">001316</idno><idno type="wicri:Area/Main/Exploration">001316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.</title><author><name sortKey="Von Brunn, Albrecht" sort="Von Brunn, Albrecht" uniqKey="Von Brunn A" first="Albrecht" last="Von Brunn">Albrecht Von Brunn</name><affiliation wicri:level="1"><nlm:affiliation>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF), Germany. Electronic address: vonbrunn@mvp.uni-muenchen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF)</wicri:regionArea><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion></affiliation></author><author><name sortKey="Ciesek, Sandra" sort="Ciesek, Sandra" uniqKey="Ciesek S" first="Sandra" last="Ciesek">Sandra Ciesek</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research (DZIF), Germany; Department of Gastroenterology, Hepatology und Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Germany; Department of Gastroenterology, Hepatology und Endocrinology, Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Von Brunn, Brigitte" sort="Von Brunn, Brigitte" uniqKey="Von Brunn B" first="Brigitte" last="Von Brunn">Brigitte Von Brunn</name><affiliation wicri:level="1"><nlm:affiliation>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF)</wicri:regionArea><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion></affiliation></author><author><name sortKey="Carbajo Lozoya, Javier" sort="Carbajo Lozoya, Javier" uniqKey="Carbajo Lozoya J" first="Javier" last="Carbajo-Lozoya">Javier Carbajo-Lozoya</name><affiliation wicri:level="1"><nlm:affiliation>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF), Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-von-Pettenkofer Institute, Ludwig-Maximilians-Universität, München, Germany; German Center for Infection Research (DZIF)</wicri:regionArea><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion><wicri:noRegion>Germany; German Center for Infection Research (DZIF)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current opinion in virology</title><idno type="eISSN">1879-6265</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus 229E, Human (physiology)</term><term>Cyclophilin A (deficiency)</term><term>Cyclophilin A (genetics)</term><term>Cyclophilin A (metabolism)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus humain 229E (physiologie)</term><term>Cyclophiline A (déficit)</term><term>Cyclophiline A (génétique)</term><term>Cyclophiline A (métabolisme)</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Polymorphisme de nucléotide simple</term><term>Réplication virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Cyclophilin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclophilin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclophilin A</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Cyclophiline A</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cyclophiline A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclophiline A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus humain 229E</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus 229E, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Host-Pathogen Interactions</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Interactions hôte-pathogène</term><term>Polymorphisme de nucléotide simple</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of several viruses. Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication. We present data on the effect of cyclophilin A single nucleotide polymorphism mutants on the replication of human CoV-229E demonstrating the requirement of proper cyclophilin A function for virus propagation. Results define cellular cyclophilin A as a host target for inhibition of coronaviruses ranging from relatively mild common cold to highly pathogenic SARS-CoV and MERS-CoV viruses with the perspective of disclosing non-immunosuppressive cyclosporin A analogs to broadly inactivate the coronavirus family. </div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Hanovre</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Von Brunn, Albrecht" sort="Von Brunn, Albrecht" uniqKey="Von Brunn A" first="Albrecht" last="Von Brunn">Albrecht Von Brunn</name></noRegion><name sortKey="Carbajo Lozoya, Javier" sort="Carbajo Lozoya, Javier" uniqKey="Carbajo Lozoya J" first="Javier" last="Carbajo-Lozoya">Javier Carbajo-Lozoya</name><name sortKey="Ciesek, Sandra" sort="Ciesek, Sandra" uniqKey="Ciesek S" first="Sandra" last="Ciesek">Sandra Ciesek</name><name sortKey="Von Brunn, Brigitte" sort="Von Brunn, Brigitte" uniqKey="Von Brunn B" first="Brigitte" last="Von Brunn">Brigitte Von Brunn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001316 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001316 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26318518
|texte= Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26318518" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |